About NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1) is a protein
from Homo sapiens identified by UniProt accession
P28331, 727 residues long.
MolForge cross-references it against 0 known binders and
294 disease associations.
Target properties
| Protein name | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial |
|---|
| UniProt accession | P28331 |
|---|
| Gene | NDUFS1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 727 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (294)
Diseases linked to this target (Open Targets).
- mitochondrial complex 1 deficiency, nuclear type 5 · score 0.77
- mitochondrial complex I deficiency · score 0.71
- type 2 diabetes mellitus · score 0.61
- diabetes mellitus · score 0.60
- polycystic ovary syndrome · score 0.60
- type 1 diabetes mellitus · score 0.58
- gestational diabetes · score 0.58
- obesity · score 0.58
- neurodegenerative disease · score 0.57
- prediabetes syndrome · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28331-F1 | alphafold | PREDICTED | 92.73 | — |
Amino-acid sequence (727 residues)
MLRIPVRKAL VGLSKSPKGC VRTTATAASN LIEVFVDGQS VMVEPGTTVL QACEKVGMQI PRFCYHERLS VAGNCRMCLV EIEKAPKVVA ACAMPVMKGW NILTNSEKSK KAREGVMEFL LANHPLDCPI CDQGGECDLQ DQSMMFGNDR SRFLEGKRAV EDKNIGPLVK TIMTRCIQCT RCIRFASEIA GVDDLGTTGR GNDMQVGTYI EKMFMSELSG NIIDICPVGA LTSKPYAFTA RPWETRKTES IDVMDAVGSN IVVSTRTGEV MRILPRMHED INEEWISDKT RFAYDGLKRQ RLTEPMVRNE KGLLTYTSWE DALSRVAGML QSFQGKDVAA IAGGLVDAEA LVALKDLLNR VDSDTLCTEE VFPTAGAGTD LRSNYLLNTT IAGVEEADVV LLVGTNPRFE APLFNARIRK SWLHNDLKVA LIGSPVDLTY TYDHLGDSPK ILQDIASGSH PFSQVLKEAK KPMVVLGSSA LQRNDGAAIL AAVSSIAQKI RMTSGVTGDW KVMNILHRIA SQVAALDLGY KPGVEAIRKN PPKVLFLLGA DGGCITRQDL PKDCFIIYQG HHGDVGAPIA DVILPGAAYT EKSATYVNTE GRAQQTKVAV TPPGLAREDW KIIRALSEIA GMTLPYDTLD QVRNRLEEVS PNLVRYDDIE GANYFQQANE LSKLVNQQLL ADPLVPPQLT IKDFYMTDSI SRASQTMAKC VKAVTEGAQA VEEPSIC
Explore NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets