Homeobox protein Hox-D10 (HOXD10)

About Homeobox protein Hox-D10

Homeobox protein Hox-D10 (HOXD10) is a protein from Homo sapiens identified by UniProt accession P28358, 340 residues long. MolForge cross-references it against 0 known binders and 163 disease associations.

Target properties

Protein name	Homeobox protein Hox-D10
UniProt accession	P28358
Gene	HOXD10
Organism	Homo sapiens
Length	340 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (163)

Diseases linked to this target (Open Targets).

congenital vertical talus · score 0.50
hemoglobin measurement · score 0.40
erythrocyte count · score 0.39
hematocrit · score 0.38
congenital vertical talus, unilateral · score 0.37
congenital vertical talus, bilateral · score 0.37
creatinine measurement · score 0.35
red blood cell density measurement · score 0.31
cystatin C measurement · score 0.27
kidney volume · score 0.25

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P28358-F1	alphafold	PREDICTED	58.89	—

Amino-acid sequence (340 residues)

MSFPNSSPAA NTFLVDSLIS ACRSDSFYSS SASMYMPPPS ADMGTYGMQT CGLLPSLAKR EVNHQNMGMN VHPYIPQVDS WTDPNRSCRI EQPVTQQVPT CSFTTNIKEE SNCCMYSDKR NKLISAEVPS YQRLVPESCP VENPEVPVPG YFRLSQTYAT GKTQEYNNSP EGSSTVMLQL NPRGAAKPQL SAAQLQMEKK MNEPVSGQEP TKVSQVESPE AKGGLPEERS CLAEVSVSSP EVQEKESKEE IKSDTPTSNW LTAKSGRKKR CPYTKHQTLE LEKEFLFNMY LTRERRLEIS KSVNLTDRQV KIWFQNRRMK LKKMSRENRI RELTANLTFS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards