About Homeobox protein MSX-1
Homeobox protein MSX-1 (MSX1) is a protein
from Homo sapiens identified by UniProt accession
P28360, 303 residues long.
MolForge cross-references it against 0 known binders and
364 disease associations.
Target properties
| Protein name | Homeobox protein MSX-1 |
|---|
| UniProt accession | P28360 |
|---|
| Gene | MSX1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 303 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (364)
Diseases linked to this target (Open Targets).
- orofacial cleft 5 · score 0.77
- tooth agenesis, selective, 1 · score 0.75
- Hypodontia - dysplasia of nails · score 0.72
- tooth and nail syndrome · score 0.46
- tooth agenesis · score 0.46
- lean body mass · score 0.37
- allergic rhinitis · score 0.37
- brain volume measurement · score 0.36
- Eczematoid dermatitis · score 0.35
- cortical surface area measurement · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28360-F1 | alphafold | PREDICTED | 64.17 | — |
Amino-acid sequence (303 residues)
MAPAADMTSL PLGVKVEDSA FGKPAGGGAG QAPSAAAATA AAMGADEEGA KPKVSPSLLP FSVEALMADH RKPGAKESAL APSEGVQAAG GSAQPLGVPP GSLGAPDAPS SPRPLGHFSV GGLLKLPEDA LVKAESPEKP ERTPWMQSPR FSPPPARRLS PPACTLRKHK TNRKPRTPFT TAQLLALERK FRQKQYLSIA ERAEFSSSLS LTETQVKIWF QNRRAKAKRL QEAELEKLKM AAKPMLPPAA FGLSFPLGGP AAVAAAAGAS LYGASGPFQR AALPVAPVGL YTAHVGYSMY HLT
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