About Gamma-aminobutyric acid receptor subunit rho-2
Gamma-aminobutyric acid receptor subunit rho-2 (GABRR2) is a protein
from Homo sapiens identified by UniProt accession
P28476, 465 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Gamma-aminobutyric acid receptor subunit rho-2 |
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| UniProt accession | P28476 |
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| Gene | GABRR2 |
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| Organism | Homo sapiens |
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| Length | 465 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (39)
Diseases linked to this target (Open Targets).
- thyroid gland adenocarcinoma · score 0.25
- cutaneous melanoma · score 0.18
- glioblastoma multiforme · score 0.18
- esophageal cancer · score 0.14
- lung adenocarcinoma · score 0.12
- squamous cell lung carcinoma · score 0.12
- Progressive sensorineural hearing impairment · score 0.11
- breast adenocarcinoma · score 0.10
- 46,XY complete gonadal dysgenesis · score 0.05
- Testicular regression syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28476-F1 | alphafold | PREDICTED | 76.55 | — |
Amino-acid sequence (465 residues)
MPYFTRLILF LFCLMVLVES RKPKRKRWTG QVEMPKPSHL YKKNLDVTKI RKGKPQQLLR VDEHDFSMRP AFGGPAIPVG VDVQVESLDS ISEVDMDFTM TLYLRHYWKD ERLAFSSASN KSMTFDGRLV KKIWVPDVFF VHSKRSFTHD TTTDNIMLRV FPDGHVLYSM RITVTAMCNM DFSHFPLDSQ TCSLELESYA YTDEDLMLYW KNGDESLKTD EKISLSQFLI QKFHTTSRLA FYSSTGWYNR LYINFTLRRH IFFFLLQTYF PATLMVMLSW VSFWIDRRAV PARVSLGITT VLTMTTIITG VNASMPRVSY VKAVDIYLWV SFVFVFLSVL EYAAVNYLTT VQERKERKLR EKFPCMCGML HSKTMMLDGS YSESEANSLA GYPRSHILTE EERQDKIVVH LGLSGEANAA RKKGLLKGQT GFRIFQNTHA IDKYSRLIFP ASYIFFNLIY WSVFS
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