Dual specificity protein phosphatase 1 (DUSP1)

About Dual specificity protein phosphatase 1

Dual specificity protein phosphatase 1 (DUSP1) is a protein from Homo sapiens identified by UniProt accession P28562, 367 residues long. MolForge cross-references it against 0 known binders and 392 disease associations.

Target properties

Protein name	Dual specificity protein phosphatase 1
UniProt accession	P28562
Gene	DUSP1
Organism	Homo sapiens
Length	367 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (392)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
mean corpuscular volume · score 0.43
C-reactive protein measurement · score 0.41
Red cell distribution width · score 0.39
diastolic blood pressure · score 0.35
mean corpuscular hemoglobin · score 0.35
cup-to-disc ratio measurement · score 0.33
birth weight · score 0.33
mean corpuscular hemoglobin concentration · score 0.32
pancreatic adenocarcinoma · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P28562-F1	alphafold	PREDICTED	79.17	—

Amino-acid sequence (367 residues)

MVMEVGTLDA GGLRALLGER AAQCLLLDCR SFFAFNAGHI AGSVNVRFST IVRRRAKGAM GLEHIVPNAE LRGRLLAGAY HAVVLLDERS AALDGAKRDG TLALAAGALC REARAAQVFF LKGGYEAFSA SCPELCSKQS TPMGLSLPLS TSVPDSAESG CSSCSTPLYD QGGPVEILPF LYLGSAYHAS RKDMLDALGI TALINVSANC PNHFEGHYQY KSIPVEDNHK ADISSWFNEA IDFIDSIKNA GGRVFVHCQA GISRSATICL AYLMRTNRVK LDEAFEFVKQ RRSIISPNFS FMGQLLQFES QVLAPHCSAE AGSPAMAVLD RGTSTTTVFN FPVSIPVHST NSALSYLQSP ITTSPSC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards