About Grancalcin
Grancalcin (GCA) is a protein
from Homo sapiens identified by UniProt accession
P28676, 217 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Grancalcin |
|---|
| UniProt accession | P28676 |
|---|
| Gene | GCA |
|---|
| Organism | Homo sapiens |
|---|
| Length | 217 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (65)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.29
- hypothyroidism · score 0.27
- type 2 diabetes mellitus · score 0.25
- psoriasis · score 0.18
- type 1 diabetes mellitus · score 0.16
- adolescent idiopathic scoliosis · score 0.15
- adrenomedullin measurement · score 0.14
- blood protein measurement · score 0.14
- leukocyte count · score 0.13
- psoriasis vulgaris · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28676-F1 | alphafold | PREDICTED | 81.32 | — |
Amino-acid sequence (217 residues)
MAYPGYGGGF GNFSIQVPGM QMGQPVPETG PAILLDGYSG PAYSDTYSSA GDSVYTYFSA VAGQDGEVDA EELQRCLTQS GINGTYSPFS LETCRIMIAM LDRDHTGKMG FNAFKELWAA LNAWKENFMT VDQDGSGTVE HHELRQAIGL MGYRLSPQTL TTIVKRYSKN GRIFFDDYVA CCVKLRALTD FFRKRDHLQQ GSANFIYDDF LQGTMAI
Explore Grancalcin with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets