About Progranulin
Progranulin (GRN) is a protein
from Homo sapiens identified by UniProt accession
P28799, 593 residues long.
MolForge cross-references it against 0 known binders and
625 disease associations.
Target properties
| Protein name | Progranulin |
|---|
| UniProt accession | P28799 |
|---|
| Gene | GRN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 593 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (625)
Diseases linked to this target (Open Targets).
- GRN-related frontotemporal lobar degeneration with Tdp43 inclusions · score 0.78
- neuronal ceroid lipofuscinosis 11 · score 0.78
- CLN11 disease · score 0.72
- frontotemporal dementia · score 0.67
- genetic disorder · score 0.49
- Primary progressive aphasia · score 0.49
- neuronal ceroid lipofuscinosis 1 · score 0.46
- dementia · score 0.41
- neuronal ceroid lipofuscinosis · score 0.38
- mental or behavioural disorder · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28799-F1 | alphafold | PREDICTED | 77.01 | — |
Amino-acid sequence (593 residues)
MWTLVSWVAL TAGLVAGTRC PDGQFCPVAC CLDPGGASYS CCRPLLDKWP TTLSRHLGGP CQVDAHCSAG HSCIFTVSGT SSCCPFPEAV ACGDGHHCCP RGFHCSADGR SCFQRSGNNS VGAIQCPDSQ FECPDFSTCC VMVDGSWGCC PMPQASCCED RVHCCPHGAF CDLVHTRCIT PTGTHPLAKK LPAQRTNRAV ALSSSVMCPD ARSRCPDGST CCELPSGKYG CCPMPNATCC SDHLHCCPQD TVCDLIQSKC LSKENATTDL LTKLPAHTVG DVKCDMEVSC PDGYTCCRLQ SGAWGCCPFT QAVCCEDHIH CCPAGFTCDT QKGTCEQGPH QVPWMEKAPA HLSLPDPQAL KRDVPCDNVS SCPSSDTCCQ LTSGEWGCCP IPEAVCCSDH QHCCPQGYTC VAEGQCQRGS EIVAGLEKMP ARRASLSHPR DIGCDQHTSC PVGQTCCPSL GGSWACCQLP HAVCCEDRQH CCPAGYTCNV KARSCEKEVV SAQPATFLAR SPHVGVKDVE CGEGHFCHDN QTCCRDNRQG WACCPYRQGV CCADRRHCCP AGFRCAARGT KCLRREAPRW DAPLRDPALR QLL
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