About Cytosol aminopeptidase
Cytosol aminopeptidase (LAP3) is a protein
from Homo sapiens identified by UniProt accession
P28838, 519 residues long.
MolForge cross-references it against 0 known binders and
304 disease associations.
Target properties
| Protein name | Cytosol aminopeptidase |
|---|
| UniProt accession | P28838 |
|---|
| Gene | LAP3 |
|---|
| Organism | Homo sapiens |
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| Length | 519 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (304)
Diseases linked to this target (Open Targets).
- acute myeloid leukemia · score 0.09
- platelet count · score 0.09
- non-alcoholic fatty liver disease · score 0.08
- platelet crit · score 0.08
- myelodysplastic syndrome · score 0.07
- neoplasm · score 0.07
- mathematical ability · score 0.07
- non-alcoholic steatohepatitis · score 0.06
- cortical thickness · score 0.06
- hepatocellular carcinoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28838-F1 | alphafold | PREDICTED | 94.21 | — |
Amino-acid sequence (519 residues)
MFLLPLPAAG RVVVRRLAVR RFGSRSLSTA DMTKGLVLGI YSKEKEDDVP QFTSAGENFD KLLAGKLRET LNISGPPLKA GKTRTFYGLH QDFPSVVLVG LGKKAAGIDE QENWHEGKEN IRAAVAAGCR QIQDLELSSV EVDPCGDAQA AAEGAVLGLY EYDDLKQKKK MAVSAKLYGS GDQEAWQKGV LFASGQNLAR QLMETPANEM TPTRFAEIIE KNLKSASSKT EVHIRPKSWI EEQAMGSFLS VAKGSDEPPV FLEIHYKGSP NANEPPLVFV GKGITFDSGG ISIKASANMD LMRADMGGAA TICSAIVSAA KLNLPINIIG LAPLCENMPS GKANKPGDVV RAKNGKTIQV DNTDAEGRLI LADALCYAHT FNPKVILNAA TLTGAMDVAL GSGATGVFTN SSWLWNKLFE ASIETGDRVW RMPLFEHYTR QVVDCQLADV NNIGKYRSAG ACTAAAFLKE FVTHPKWAHL DIAGVMTNKD EVPYLRKGMT GRPTRTLIEF LLRFSQDNA
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