General transcription factor IIE subunit 1 (GTF2E1)

About General transcription factor IIE subunit 1

General transcription factor IIE subunit 1 (GTF2E1) is a protein from Homo sapiens identified by UniProt accession P29083, 439 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	General transcription factor IIE subunit 1
UniProt accession	P29083
Gene	GTF2E1
Organism	Homo sapiens
Length	439 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

HIV infection · score 0.58
neurodegenerative disease · score 0.53
pancreatic adenocarcinoma · score 0.18
preeclampsia · score 0.03
hepatocellular carcinoma · score 0.00
Systemic lupus erythematosus · score 0.00
invasive breast ductal carcinoma · score 0.00
cancer · score 0.00
xeroderma pigmentosum · score 0.00
retinal degeneration · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P29083-F1	alphafold	PREDICTED	66.67	—

Amino-acid sequence (439 residues)

MADPDVLTEV PAALKRLAKY VIRGFYGIEH ALALDILIRN SCVKEEDMLE LLKFDRKQLR SVLNNLKGDK FIKCRMRVET AADGKTTRHN YYFINYRTLV NVVKYKLDHM RRRIETDERD STNRASFKCP VCSSTFTDLE ANQLFDPMTG TFRCTFCHTE VEEDESAMPK KDARTLLARF NEQIEPIYAL LRETEDVNLA YEILEPEPTE IPALKQSKDH AATTAGAASL AGGHHREAWA TKGPSYEDLY TQNVVINMDD QEDLHRASLE GKSAKERPIW LRESTVQGAY GSEDMKEGGI DMDAFQEREE GHAGPDDNEE VMRALLIHEK KTSSAMAGSV GAAAPVTAAN GSDSESETSE SDDDSPPRPA AVAVHKREED EEEDDEFEEV ADDPIVMVAG RPFSYSEVSQ RPELVAQMTP EEKEAYIAMG QRMFEDLFE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards