Proprotein convertase subtilisin/kexin type 6 (PCSK6)

About Proprotein convertase subtilisin/kexin type 6

Proprotein convertase subtilisin/kexin type 6 (PCSK6) is a protein from Homo sapiens identified by UniProt accession P29122, 969 residues long. MolForge cross-references it against 0 known binders and 221 disease associations.

Target properties

Protein name	Proprotein convertase subtilisin/kexin type 6
UniProt accession	P29122
Gene	PCSK6
Organism	Homo sapiens
Length	969 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (221)

Diseases linked to this target (Open Targets).

platelet-derived growth factor BB measurement · score 0.46
blood protein measurement · score 0.45
body height · score 0.42
inflammatory biomarker measurement · score 0.38
interleukin 10 measurement · score 0.38
interleukin 12 measurement · score 0.38
interleukin-6 measurement · score 0.38
vascular endothelial growth factor measurement · score 0.38
fibroblast growth factor basic measurement · score 0.38
granulocyte colony-stimulating factor measurement · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P29122-F1	alphafold	PREDICTED	81.40	—

Amino-acid sequence (969 residues)

MPPRAPPAPG PRPPPRAAAA TDTAAGAGGA GGAGGAGGPG FRPLAPRPWR WLLLLALPAA CSAPPPRPVY TNHWAVQVLG GPAEADRVAA AHGYLNLGQI GNLEDYYHFY HSKTFKRSTL SSRGPHTFLR MDPQVKWLQQ QEVKRRVKRQ VRSDPQALYF NDPIWSNMWY LHCGDKNSRC RSEMNVQAAW KRGYTGKNVV VTILDDGIER NHPDLAPNYD SYASYDVNGN DYDPSPRYDA SNENKHGTRC AGEVAASANN SYCIVGIAYN AKIGGIRMLD GDVTDVVEAK SLGIRPNYID IYSASWGPDD DGKTVDGPGR LAKQAFEYGI KKGRQGLGSI FVWASGNGGR EGDYCSCDGY TNSIYTISVS SATENGYKPW YLEECASTLA TTYSSGAFYE RKIVTTDLRQ RCTDGHTGTS VSAPMVAGII ALALEANSQL TWRDVQHLLV KTSRPAHLKA SDWKVNGAGH KVSHFYGFGL VDAEALVVEA KKWTAVPSQH MCVAASDKRP RSIPLVQVLR TTALTSACAE HSDQRVVYLE HVVVRTSISH PRRGDLQIYL VSPSGTKSQL LAKRLLDLSN EGFTNWEFMT VHCWGEKAEG QWTLEIQDLP SQVRNPEKQG KLKEWSLILY GTAEHPYHTF SAHQSRSRML ELSAPELEPP KAALSPSQVE VPEDEEDYTA QSTPGSANIL QTSVCHPECG DKGCDGPNAD QCLNCVHFSL GSVKTSRKCV SVCPLGYFGD TAARRCRRCH KGCETCSSRA ATQCLSCRRG FYHHQEMNTC VTLCPAGFYA DESQKNCLKC HPSCKKCVDE PEKCTVCKEG FSLARGSCIP DCEPGTYFDS ELIRCGECHH TCGTCVGPGR EECIHCAKNF HFHDWKCVPA CGEGFYPEEM PGLPHKVCRR CDENCLSCAG SSRNCSRCKT GFTQLGTSCI TNHTCSNADE TFCEMVKSNR LCERKLFIQF CCRTCLLAG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards