Inositol monophosphatase 1 (IMPA1)

About Inositol monophosphatase 1

Inositol monophosphatase 1 (IMPA1) is a protein from Homo sapiens identified by UniProt accession P29218, 277 residues long. MolForge cross-references it against 0 known binders and 151 disease associations.

Target properties

Protein name	Inositol monophosphatase 1
UniProt accession	P29218
Gene	IMPA1
Organism	Homo sapiens
Length	277 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (151)

Diseases linked to this target (Open Targets).

bipolar disorder · score 0.61
depressive disorder · score 0.58
bipolar I disorder · score 0.58
major depressive disorder · score 0.53
intellectual disability, autosomal recessive 59 · score 0.52
schizophrenia · score 0.46
neurodegenerative disease · score 0.41
HIV infection · score 0.37
Acute kidney injury · score 0.37
osteosarcoma · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P29218-F1	alphafold	PREDICTED	96.21	—

Amino-acid sequence (277 residues)

MADPWQECMD YAVTLARQAG EVVCEAIKNE MNVMLKSSPV DLVTATDQKV EKMLISSIKE KYPSHSFIGE ESVAAGEKSI LTDNPTWIID PIDGTTNFVH RFPFVAVSIG FAVNKKIEFG VVYSCVEGKM YTARKGKGAF CNGQKLQVSQ QEDITKSLLV TELGSSRTPE TVRMVLSNME KLFCIPVHGI RSVGTAAVNM CLVATGGADA YYEMGIHCWD VAGAGIIVTE AGGVLMDVTG GPFDLMSRRV IAANNRILAE RIAKEIQVIP LQRDDED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards