CCN family member 2 (CCN2)

About CCN family member 2

CCN family member 2 (CCN2) is a protein from Homo sapiens identified by UniProt accession P29279, 349 residues long. MolForge cross-references it against 0 known binders and 930 disease associations.

Target properties

Protein name	CCN family member 2
UniProt accession	P29279
Gene	CCN2
Organism	Homo sapiens
Length	349 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (930)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.34
pancreatic carcinoma · score 0.33
idiopathic pulmonary fibrosis · score 0.31
pancreatic adenocarcinoma · score 0.26
body height · score 0.24
blood phosphate measurement · score 0.19
Duchenne muscular dystrophy · score 0.18
neoplasm · score 0.12
hepatocellular carcinoma · score 0.11
Rheumatoid arthritis · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P29279-F1	alphafold	PREDICTED	78.37	—

Amino-acid sequence (349 residues)

MTAASMGPVR VAFVVLLALC SRPAVGQNCS GPCRCPDEPA PRCPAGVSLV LDGCGCCRVC AKQLGELCTE RDPCDPHKGL FCHFGSPANR KIGVCTAKDG APCIFGGTVY RSGESFQSSC KYQCTCLDGA VGCMPLCSMD VRLPSPDCPF PRRVKLPGKC CEEWVCDEPK DQTVVGPALA AYRLEDTFGP DPTMIRANCL VQTTEWSACS KTCGMGISTR VTNDNASCRL EKQSRLCMVR PCEADLEENI KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT LPVEFKCPDG EVMKKNMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards