About SHC-transforming protein 1
SHC-transforming protein 1 (SHC1) is a protein
from Homo sapiens identified by UniProt accession
P29353, 583 residues long.
MolForge cross-references it against 0 known binders and
317 disease associations.
Target properties
| Protein name | SHC-transforming protein 1 |
|---|
| UniProt accession | P29353 |
|---|
| Gene | SHC1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 583 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (317)
Diseases linked to this target (Open Targets).
- cancer · score 0.61
- lung adenocarcinoma · score 0.32
- thyroid gland adenocarcinoma · score 0.30
- acute myeloid leukemia · score 0.30
- breast adenocarcinoma · score 0.30
- endometrial cancer · score 0.30
- cutaneous melanoma · score 0.30
- head and neck squamous cell carcinoma · score 0.29
- low grade glioma · score 0.28
- neurodegenerative disease · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P29353-F1 | alphafold | PREDICTED | 62.42 | — |
Amino-acid sequence (583 residues)
MDLLPPKPKY NPLRNESLSS LEEGASGSTP PEELPSPSAS SLGPILPPLP GDDSPTTLCS FFPRMSNLRL ANPAGGRPGS KGEPGRAADD GEGIVGAAMP DSGPLPLLQD MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL GGVVDMRLRE GAAPGAARPT APNAQTPSHL GATLPVGQPV GGDPEVRKQM PPPPPCPGRE LFDDPSYVNV QNLDKARQAV GGAGPPNPAI NGSAPRDLFD MKPFEDALRV PPPPQSVSMA EQLRGEPWFH GKLSRREAEA LLQLNGDFLV RESTTTPGQY VLTGLQSGQP KHLLLVDPEG VVRTKDHRFE SVSHLISYHM DNHLPIISAG SELCLQQPVE RKL
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