About Neuromedin-K receptor
Neuromedin-K receptor (TACR3) is a protein
from Homo sapiens identified by UniProt accession
P29371, 465 residues long.
MolForge cross-references it against 0 known binders and
175 disease associations.
Target properties
| Protein name | Neuromedin-K receptor |
|---|
| UniProt accession | P29371 |
|---|
| Gene | TACR3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 465 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (175)
Diseases linked to this target (Open Targets).
- isolated congenital hypogonadotropic hypogonadism · score 0.63
- hypogonadotropic hypogonadism · score 0.58
- age at menarche · score 0.53
- Hot flashes · score 0.52
- Hypogonadotropic hypogonadism · score 0.51
- testosterone measurement · score 0.48
- BMI-adjusted hip circumference · score 0.41
- isolated thyroid-stimulating hormone deficiency · score 0.41
- heel bone mineral density · score 0.40
- Kallmann syndrome · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P29371-F1 | alphafold | PREDICTED | 72.80 | — |
Amino-acid sequence (465 residues)
MATLPAAETW IDGGGGVGAD AVNLTASLAA GAATGAVETG WLQLLDQAGN LSSSPSALGL PVASPAPSQP WANLTNQFVQ PSWRIALWSL AYGVVVAVAV LGNLIVIWII LAHKRMRTVT NYFLVNLAFS DASMAAFNTL VNFIYALHSE WYFGANYCRF QNFFPITAVF ASIYSMTAIA VDRYMAIIDP LKPRLSATAT KIVIGSIWIL AFLLAFPQCL YSKTKVMPGR TLCFVQWPEG PKQHFTYHII VIILVYCFPL LIMGITYTIV GITLWGGEIP GDTCDKYHEQ LKAKRKVVKM MIIVVMTFAI CWLPYHIYFI LTAIYQQLNR WKYIQQVYLA SFWLAMSSTM YNPIIYCCLN KRFRAGFKRA FRWCPFIKVS SYDELELKTT RFHPNRQSSM YTVTRMESMT VVFDPNDADT TRSSRKKRAT PRDPSFNGCS RRNSKSASAT SSFISSPYTS VDEYS
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