Cellular retinoic acid-binding protein 2 (CRABP2)

About Cellular retinoic acid-binding protein 2

Cellular retinoic acid-binding protein 2 (CRABP2) is a protein from Homo sapiens identified by UniProt accession P29373, 138 residues long. MolForge cross-references it against 0 known binders and 186 disease associations.

Target properties

Protein name	Cellular retinoic acid-binding protein 2
UniProt accession	P29373
Gene	CRABP2
Organism	Homo sapiens
Length	138 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (186)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
neutrophil count · score 0.20
leukocyte count · score 0.20
non-small cell lung carcinoma · score 0.11
neoplasm · score 0.11
postaxial polydactyly type A · score 0.10
esophageal squamous cell carcinoma · score 0.10
breast cancer · score 0.09
Oliver syndrome · score 0.09
polydactyly, postaxial, A9 · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P29373-F1	alphafold	PREDICTED	96.72	—

Amino-acid sequence (138 residues)

MPNFSGNWKI IRSENFEELL KVLGVNVMLR KIAVAAASKP AVEIKQEGDT FYIKTSTTVR TTEINFKVGE EFEEQTVDGR PCKSLVKWES ENKMVCEQKL LKGEGPKTSW TRELTNDGEL ILTMTADDVV CTRVYVRE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards