About Interleukin-12 subunit alpha
Interleukin-12 subunit alpha (IL12A) is a protein
from Homo sapiens identified by UniProt accession
P29459, 219 residues long.
MolForge cross-references it against 0 known binders and
261 disease associations.
Target properties
| Protein name | Interleukin-12 subunit alpha |
|---|
| UniProt accession | P29459 |
|---|
| Gene | IL12A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 219 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (261)
Diseases linked to this target (Open Targets).
- primary biliary cirrhosis · score 0.46
- lymphocyte count · score 0.39
- biliary liver cirrhosis · score 0.38
- celiac disease · score 0.37
- multiple sclerosis · score 0.36
- Behcet's syndrome · score 0.35
- Sjogren syndrome · score 0.29
- cortical surface area measurement · score 0.27
- systemic scleroderma · score 0.27
- systemic lupus erythematosus · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P29459-F1 | alphafold | PREDICTED | 78.97 | — |
Amino-acid sequence (219 residues)
MCPARSLLLV ATLVLLDHLS LARNLPVATP DPGMFPCLHH SQNLLRAVSN MLQKARQTLE FYPCTSEEID HEDITKDKTS TVEACLPLEL TKNESCLNSR ETSFITNGSC LASRKTSFMM ALCLSSIYED LKMYQVEFKT MNAKLLMDPK RQIFLDQNML AVIDELMQAL NFNSETVPQK SSLEEPDFYK TKIKLCILLH AFRIRAVTID RVMSYLNAS
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