About Interleukin-12 subunit beta
Interleukin-12 subunit beta (IL12B) is a protein
from Homo sapiens identified by UniProt accession
P29460, 328 residues long.
MolForge cross-references it against 0 known binders and
390 disease associations.
Target properties
| Protein name | Interleukin-12 subunit beta |
|---|
| UniProt accession | P29460 |
|---|
| Gene | IL12B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 328 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (390)
Diseases linked to this target (Open Targets).
- psoriasis · score 0.72
- Crohn's disease · score 0.69
- psoriatic arthritis · score 0.64
- ulcerative colitis · score 0.60
- psoriasis vulgaris · score 0.56
- inflammatory bowel disease · score 0.48
- immune system disease · score 0.44
- ankylosing spondylitis · score 0.42
- skin disease · score 0.40
- autoimmune disease · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P29460-F1 | alphafold | PREDICTED | 91.11 | — |
Amino-acid sequence (328 residues)
MCHQQLVISW FSLVFLASPL VAIWELKKDV YVVELDWYPD APGEMVVLTC DTPEEDGITW TLDQSSEVLG SGKTLTIQVK EFGDAGQYTC HKGGEVLSHS LLLLHKKEDG IWSTDILKDQ KEPKNKTFLR CEAKNYSGRF TCWWLTTIST DLTFSVKSSR GSSDPQGVTC GAATLSAERV RGDNKEYEYS VECQEDSACP AAEESLPIEV MVDAVHKLKY ENYTSSFFIR DIIKPDPPKN LQLKPLKNSR QVEVSWEYPD TWSTPHSYFS LTFCVQVQGK SKREKKDRVF TDKTSATVIC RKNASISVRA QDRYYSSSWS EWASVPCS
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