About Caspase-1
Caspase-1 (CASP1) is a protein
from Homo sapiens identified by UniProt accession
P29466, 404 residues long.
MolForge cross-references it against 0 known binders and
843 disease associations.
Target properties
| Protein name | Caspase-1 |
|---|
| UniProt accession | P29466 |
|---|
| Gene | CASP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 404 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (843)
Diseases linked to this target (Open Targets).
- severe acute respiratory syndrome · score 0.37
- lung adenocarcinoma · score 0.27
- glioblastoma multiforme · score 0.26
- ovarian cancer · score 0.25
- breast adenocarcinoma · score 0.25
- head and neck squamous cell carcinoma · score 0.24
- squamous cell lung carcinoma · score 0.23
- gastric adenocarcinoma · score 0.23
- endometrial cancer · score 0.23
- chronic lymphocytic leukemia · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P29466-F1 | alphafold | PREDICTED | 81.68 | — |
Amino-acid sequence (404 residues)
MADKVLKEKR KLFIRSMGEG TINGLLDELL QTRVLNKEEM EKVKRENATV MDKTRALIDS VIPKGAQACQ ICITYICEED SYLAGTLGLS ADQTSGNYLN MQDSQGVLSS FPAPQAVQDN PAMPTSSGSE GNVKLCSLEE AQRIWKQKSA EIYPIMDKSS RTRLALIICN EEFDSIPRRT GAEVDITGMT MLLQNLGYSV DVKKNLTASD MTTELEAFAH RPEHKTSDST FLVFMSHGIR EGICGKKHSE QVPDILQLNA IFNMLNTKNC PSLKDKPKVI IIQACRGDSP GVVWFKDSVG VSGNLSLPTT EEFEDDAIKK AHIEKDFIAF CSSTPDNVSW RHPTMGSVFI GRLIEHMQEY ACSCDVEEIF RKVRFSFEQP DGRAQMPTTE RVTLTRCFYL FPGH
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