Serpin B3 (SERPINB3)

About Serpin B3

Serpin B3 (SERPINB3) is a protein from Homo sapiens identified by UniProt accession P29508, 390 residues long. MolForge cross-references it against 0 known binders and 280 disease associations.

Target properties

Protein name	Serpin B3
UniProt accession	P29508
Gene	SERPINB3
Organism	Homo sapiens
Length	390 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (280)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.21
cutaneous melanoma · score 0.18
neoplasm · score 0.11
hepatocellular carcinoma · score 0.10
head and neck squamous cell carcinoma · score 0.08
vitamin D measurement · score 0.08
psoriasis · score 0.08
cholangiocarcinoma · score 0.06
glioblastoma multiforme · score 0.06
protein measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P29508-F1	alphafold	PREDICTED	89.29	—

Amino-acid sequence (390 residues)

MNSLSEANTK FMFDLFQQFR KSKENNIFYS PISITSALGM VLLGAKDNTA QQIKKVLHFD QVTENTTGKA ATYHVDRSGN VHHQFQKLLT EFNKSTDAYE LKIANKLFGE KTYLFLQEYL DAIKKFYQTS VESVDFANAP EESRKKINSW VESQTNEKIK NLIPEGNIGS NTTLVLVNAI YFKGQWEKKF NKEDTKEEKF WPNKNTYKSI QMMRQYTSFH FASLEDVQAK VLEIPYKGKD LSMIVLLPNE IDGLQKLEEK LTAEKLMEWT SLQNMRETRV DLHLPRFKVE ESYDLKDTLR TMGMVDIFNG DADLSGMTGS RGLVLSGVLH KAFVEVTEEG AEAAAATAVV GFGSSPTSTN EEFHCNHPFL FFIRQNKTNS ILFYGRFSSP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards