About Leiomodin-1
Leiomodin-1 (LMOD1) is a protein
from Homo sapiens identified by UniProt accession
P29536, 600 residues long.
MolForge cross-references it against 0 known binders and
157 disease associations.
Target properties
| Protein name | Leiomodin-1 |
|---|
| UniProt accession | P29536 |
|---|
| Gene | LMOD1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 600 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (157)
Diseases linked to this target (Open Targets).
- megacystis-microcolon-intestinal hypoperistalsis syndrome 3 · score 0.60
- megacystis-microcolon-intestinal hypoperistalsis syndrome · score 0.37
- appendicular lean mass · score 0.37
- visceral myopathy 1 · score 0.33
- familial visceral myopathy · score 0.33
- coronary artery disease · score 0.28
- FEV/FVC ratio · score 0.28
- body mass index · score 0.26
- physical activity measurement · score 0.21
- diastolic blood pressure · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P29536-F1 | alphafold | PREDICTED | 63.44 | — |
Amino-acid sequence (600 residues)
MSRVAKYRRQ VSEDPDIDSL LETLSPEEME ELEKELDVVD PDGSVPVGLR QRNQTEKQST GVYNREAMLN FCEKETKKLM QREMSMDESK QVETKTDAKN GEERGRDASK KALGPRRDSD LGKEPKRGGL KKSFSRDRDE AGGKSGEKPK EEKIIRGIDK GRVRAAVDKK EAGKDGRGEE RAVATKKEEE KKGSDRNTGL SRDKDKKREE MKEVAKKEDD EKVKGERRNT DTRKEGEKMK RAGGNTDMKK EDEKVKRGTG NTDTKKDDEK VKKNEPLHEK EAKDDSKTKT PEKQTPSGPT KPSEGPAKVE EEAAPSIFDE PLERVKNNDP EMTEVNVNNS DCITNEILVR FTEALEFNTV VKLFALANTR ADDHVAFAIA IMLKANKTIT SLNLDSNHIT GKGILAIFRA LLQNNTLTEL RFHNQRHICG GKTEMEIAKL LKENTTLLKL GYHFELAGPR MTVTNLLSRN MDKQRQKRLQ EQRQAQEAKG EKKDLLEVPK AGAVAKGSPK PSPQPSPKPS PKNSPKKGGA PAAPPPPPPP LAPPLIMENL KNSLSPATQR KMGDKVLPAQ EKNSRDQLLA AIRSSNLKQL KKVEVPKLLQ
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