About 2'-5'-oligoadenylate synthase 2
2'-5'-oligoadenylate synthase 2 (OAS2) is a protein
from Homo sapiens identified by UniProt accession
P29728, 719 residues long.
MolForge cross-references it against 0 known binders and
155 disease associations.
Target properties
| Protein name | 2'-5'-oligoadenylate synthase 2 |
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| UniProt accession | P29728 |
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| Gene | OAS2 |
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| Organism | Homo sapiens |
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| Length | 719 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (155)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.22
- alcohol drinking · score 0.11
- blood protein measurement · score 0.10
- psoriasis · score 0.10
- high density lipoprotein cholesterol measurement · score 0.09
- COVID-19 · score 0.09
- alcohol consumption measurement · score 0.09
- Systemic lupus erythematosus · score 0.06
- type 2 diabetes mellitus · score 0.06
- hypertension · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P29728-F1 | alphafold | PREDICTED | 88.36 | — |
Amino-acid sequence (719 residues)
MGNGESQLSS VPAQKLGWFI QEYLKPYEEC QTLIDEMVNT ICDVLQEPEQ FPLVQGVAIG GSYGRKTVLR GNSDGTLVLF FSDLKQFQDQ KRSQRDILDK TGDKLKFCLF TKWLKNNFEI QKSLDGFTIQ VFTKNQRISF EVLAAFNALS LNDNPSPWIY RELKRSLDKT NASPGEFAVC FTELQQKFFD NRPGKLKDLI LLIKHWHQQC QKKIKDLPSL SPYALELLTV YAWEQGCRKD NFDIAEGVRT VLELIKCQEK LCIYWMVNYN FEDETIRNIL LHQLQSARPV ILDPVDPTNN VSGDKICWQW LKKEAQTWLT SPNLDNELPA PSWNVLPAPL FTTPGHLLDK FIKEFLQPNK CFLEQIDSAV NIIRTFLKEN CFRQSTAKIQ IVRGGSTAKG TALKTGSDAD LVVFHNSLKS YTSQKNERHK IVKEIHEQLK AFWREKEEEL EVSFEPPKWK APRVLSFSLK SKVLNESVSF DVLPAFNALG QLSSGSTPSP EVYAGLIDLY KSSDLPGGEF STCFTVLQRN FIRSRPTKLK DLIRLVKHWY KECERKLKPK GSLPPKYALE LLTIYAWEQG SGVPDFDTAE GFRTVLELVT QYQQLCIFWK VNYNFEDETV RKFLLSQLQK TRPVILDPAE PTGDVGGGDR WCWHLLAKEA KEWLSSPCFK DGTGNPIPPW KVPTMQTPGS CGARIHPIVN EMFSSRSHRI LNNNSKRNF
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