About Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (PDHA2) is a protein
from Homo sapiens identified by UniProt accession
P29803, 388 residues long.
MolForge cross-references it against 0 known binders and
32 disease associations.
Target properties
| Protein name | Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial |
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| UniProt accession | P29803 |
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| Gene | PDHA2 |
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| Organism | Homo sapiens |
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| Length | 388 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (32)
Diseases linked to this target (Open Targets).
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.45
- spermatogenic failure 70 · score 0.45
- azoospermia · score 0.33
- brain measurement · score 0.26
- white matter microstructure measurement · score 0.23
- gut microbiome measurement · score 0.21
- chemotherapy-induced cytotoxicity measurement · score 0.20
- self reported educational attainment · score 0.20
- protein measurement · score 0.17
- neurodegenerative disease · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P29803-F1 | alphafold | PREDICTED | 94.14 | — |
Amino-acid sequence (388 residues)
MLAAFISRVL RRVAQKSARR VLVASRNSSN DATFEIKKCD LYLLEEGPPV TTVLTRAEGL KYYRMMLTVR RMELKADQLY KQKFIRGFCH LCDGQEACCV GLEAGINPSD HVITSYRAHG VCYTRGLSVR SILAELTGRR GGCAKGKGGS MHMYTKNFYG GNGIVGAQGP LGAGIALACK YKGNDEICLT LYGDGAANQG QIAEAFNMAA LWKLPCVFIC ENNLYGMGTS TERAAASPDY YKRGNFIPGL KVDGMDVLCV REATKFAANY CRSGKGPILM ELQTYRYHGH SMSDPGVSYR TREEIQEVRS KRDPIIILQD RMVNSKLATV EELKEIGAEV RKEIDDAAQF ATTDPEPHLE ELGHHIYSSD SSFEVRGANP WIKFKSVS
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