Myristoylated alanine-rich C-kinase substrate (MARCKS)

About Myristoylated alanine-rich C-kinase substrate

Myristoylated alanine-rich C-kinase substrate (MARCKS) is a protein from Homo sapiens identified by UniProt accession P29966, 332 residues long. MolForge cross-references it against 0 known binders and 191 disease associations.

Target properties

Protein name	Myristoylated alanine-rich C-kinase substrate
UniProt accession	P29966
Gene	MARCKS
Organism	Homo sapiens
Length	332 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (191)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.47
heel bone mineral density · score 0.37
monocyte count · score 0.35
self reported educational attainment · score 0.31
monocyte percentage of leukocytes · score 0.31
mathematical ability · score 0.23
PR interval · score 0.22
physical activity measurement · score 0.20
bone density · score 0.17
urate measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P29966-F1	alphafold	PREDICTED	49.57	—

Amino-acid sequence (332 residues)

MGAQFSKTAA KGEAAAERPG EAAVASSPSK ANGQENGHVK VNGDASPAAA ESGAKEELQA NGSAPAADKE EPAAAGSGAA SPSAAEKGEP AAAAAPEAGA SPVEKEAPAE GEAAEPGSPT AAEGEAASAA SSTSSPKAED GATPSPSNET PKKKKKRFSF KKSFKLSGFS FKKNKKEAGE GGEAEAPAAE GGKDEAAGGA AAAAAEAGAA SGEQAAAPGE EAAAGEEGAA GGDPQEAKPQ EAAVAPEKPP ASDETKAAEE PSKVEEKKAE EAGASAAACE APSAAGPGAP PEQEAAPAEE PAAAAASSAC AAPSQEAQPE CSPEAPPAEA AE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards