About Aquaporin-1
Aquaporin-1 (AQP1) is a protein
from Homo sapiens identified by UniProt accession
P29972, 269 residues long.
MolForge cross-references it against 0 known binders and
204 disease associations.
Target properties
| Protein name | Aquaporin-1 |
|---|
| UniProt accession | P29972 |
|---|
| Gene | AQP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 269 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (204)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.45
- bone density · score 0.43
- bone quantitative ultrasound measurement · score 0.42
- body height · score 0.38
- hemolysis · score 0.37
- osteoporosis · score 0.36
- urate measurement · score 0.34
- bone fracture · score 0.30
- bone disease · score 0.29
- nephrolithiasis · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P29972-F1 | alphafold | PREDICTED | 90.76 | — |
Amino-acid sequence (269 residues)
MASEFKKKLF WRAVVAEFLA TTLFVFISIG SALGFKYPVG NNQTAVQDNV KVSLAFGLSI ATLAQSVGHI SGAHLNPAVT LGLLLSCQIS IFRALMYIIA QCVGAIVATA ILSGITSSLT GNSLGRNDLA DGVNSGQGLG IEIIGTLQLV LCVLATTDRR RRDLGGSAPL AIGLSVALGH LLAIDYTGCG INPARSFGSA VITHNFSNHW IFWVGPFIGG ALAVLIYDFI LAPRSSDLTD RVKVWTSGQV EEYDLDADDI NSRVEMKPK
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