About Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (ALDH4A1) is a protein
from Homo sapiens identified by UniProt accession
P30038, 563 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial |
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| UniProt accession | P30038 |
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| Gene | ALDH4A1 |
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| Organism | Homo sapiens |
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| Length | 563 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (63)
Diseases linked to this target (Open Targets).
- hyperprolinemia type 2 · score 0.76
- Intellectual disability · score 0.50
- metabolite measurement · score 0.20
- hyperprolinemia · score 0.18
- plasminogen activator inhibitor 1 measurement · score 0.06
- schizophrenia · score 0.03
- PHF-tau measurement · score 0.03
- neurofibrillary tangles measurement · score 0.03
- clear cell renal carcinoma · score 0.03
- atherosclerosis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30038-F1 | alphafold | PREDICTED | 96.20 | — |
Amino-acid sequence (563 residues)
MLLPAPALRR ALLSRPWTGA GLRWKHTSSL KVANEPVLAF TQGSPERDAL QKALKDLKGR MEAIPCVVGD EEVWTSDVQY QVSPFNHGHK VAKFCYADKS LLNKAIEAAL AARKEWDLKP IADRAQIFLK AADMLSGPRR AEILAKTMVG QGKTVIQAEI DAAAELIDFF RFNAKYAVEL EGQQPISVPP STNSTVYRGL EGFVAAISPF NFTAIGGNLA GAPALMGNVV LWKPSDTAML ASYAVYRILR EAGLPPNIIQ FVPADGPLFG DTVTSSEHLC GINFTGSVPT FKHLWKQVAQ NLDRFHTFPR LAGECGGKNF HFVHRSADVE SVVSGTLRSA FEYGGQKCSA CSRLYVPHSL WPQIKGRLLE EHSRIKVGDP AEDFGTFFSA VIDAKSFARI KKWLEHARSS PSLTILAGGK CDDSVGYFVE PCIVESKDPQ EPIMKEEIFG PVLSVYVYPD DKYKETLQLV DSTTSYGLTG AVFSQDKDVV QEATKVLRNA AGNFYINDKS TGSIVGQQPF GGARASGTND KPGGPHYILR WTSPQVIKET HKPLGDWSYA YMQ
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