D-dopachrome decarboxylase (DDT)

About D-dopachrome decarboxylase

D-dopachrome decarboxylase (DDT) is a protein from Homo sapiens identified by UniProt accession P30046, 118 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.

Target properties

Protein name	D-dopachrome decarboxylase
UniProt accession	P30046
Gene	DDT
Organism	Homo sapiens
Length	118 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (62)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.34
multiple sclerosis · score 0.23
Parkinson disease · score 0.22
lysosomal storage disease · score 0.22
Alzheimer disease · score 0.22
serum gamma-glutamyl transferase measurement · score 0.19
IGF-1 measurement · score 0.18
sex hormone-binding globulin measurement · score 0.17
insulin like growth factor measurement · score 0.13
protein measurement · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P30046-F1	alphafold	PREDICTED	97.97	—

Amino-acid sequence (118 residues)

MPFLELDTNL PANRVPAGLE KRLCAAAASI LGKPADRVNV TVRPGLAMAL SGSTEPCAQL SISSIGVVGT AEDNRSHSAH FFEFLTKELA LGQDRILIRF FPLESWQIGK IGTVMTFL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards