GTP cyclohydrolase 1 feedback regulatory protein…

About GTP cyclohydrolase 1 feedback regulatory protein

GTP cyclohydrolase 1 feedback regulatory protein (GCHFR) is a protein from Homo sapiens identified by UniProt accession P30047, 84 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.

Target properties

Protein name	GTP cyclohydrolase 1 feedback regulatory protein
UniProt accession	P30047
Gene	GCHFR
Organism	Homo sapiens
Length	84 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (25)

Diseases linked to this target (Open Targets).

triglyceride measurement · score 0.21
mean corpuscular volume · score 0.07
mean reticulocyte volume · score 0.05
mean platelet volume · score 0.05
sex hormone-binding globulin measurement · score 0.04
mean corpuscular hemoglobin concentration · score 0.04
mean corpuscular hemoglobin · score 0.03
prostate carcinoma · score 0.03
type 2 diabetes mellitus · score 0.02
mathematical ability · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P30047-F1	alphafold	PREDICTED	97.91	—

Amino-acid sequence (84 residues)

MPYLLISTQI RMEVGPTMVG DEQSDPELMQ HLGASKRRAL GNNFYEYYVD DPPRIVLDKL ERRGFRVLSM TGVGQTLVWC LHKE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

GTP cyclohydrolase 1 feedback regulatory protein (GCHFR)