About Enoyl-CoA hydratase, mitochondrial
Enoyl-CoA hydratase, mitochondrial (ECHS1) is a protein
from Homo sapiens identified by UniProt accession
P30084, 290 residues long.
MolForge cross-references it against 0 known binders and
155 disease associations.
Target properties
| Protein name | Enoyl-CoA hydratase, mitochondrial |
|---|
| UniProt accession | P30084 |
|---|
| Gene | ECHS1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 290 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (155)
Diseases linked to this target (Open Targets).
- mitochondrial short-chain Enoyl-Coa hydratase 1 deficiency · score 0.85
- genetic disorder · score 0.49
- Leigh syndrome · score 0.46
- neurodegenerative disease · score 0.37
- longevity · score 0.20
- neoplasm · score 0.09
- gonorrhea · score 0.08
- cancer · score 0.08
- Gollop-Wolfgang complex · score 0.06
- tibial hemimelia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30084-F1 | alphafold | PREDICTED | 91.69 | — |
Amino-acid sequence (290 residues)
MAALRVLLSC VRGPLRPPVR CPAWRPFASG ANFEYIIAEK RGKNNTVGLI QLNRPKALNA LCDGLIDELN QALKTFEEDP AVGAIVLTGG DKAFAAGADI KEMQNLSFQD CYSSKFLKHW DHLTQVKKPV IAAVNGYAFG GGCELAMMCD IIYAGEKAQF AQPEILIGTI PGAGGTQRLT RAVGKSLAME MVLTGDRISA QDAKQAGLVS KICPVETLVE EAIQCAEKIA SNSKIVVAMA KESVNAAFEM TLTEGSKLEK KLFYSTFATD DRKEGMTAFV EKRKANFKDQ
Explore Enoyl-CoA hydratase, mitochondrial with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets