About Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) is a protein
from Homo sapiens identified by UniProt accession
P30153, 589 residues long.
MolForge cross-references it against 0 known binders and
251 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform |
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| UniProt accession | P30153 |
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| Gene | PPP2R1A |
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| Organism | Homo sapiens |
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| Length | 589 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (251)
Diseases linked to this target (Open Targets).
- Houge-Janssens syndrome 2 · score 0.76
- Intellectual disability · score 0.63
- endometrial cancer · score 0.60
- neurodegenerative disease · score 0.56
- cancer · score 0.54
- Uterine Carcinosarcoma · score 0.51
- genetic disorder · score 0.50
- lung adenocarcinoma · score 0.46
- head and neck squamous cell carcinoma · score 0.45
- gastric adenocarcinoma · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30153-F1 | alphafold | PREDICTED | 94.94 | — |
Amino-acid sequence (589 residues)
MAAADGDDSL YPIAVLIDEL RNEDVQLRLN SIKKLSTIAL ALGVERTRSE LLPFLTDTIY DEDEVLLALA EQLGTFTTLV GGPEYVHCLL PPLESLATVE ETVVRDKAVE SLRAISHEHS PSDLEAHFVP LVKRLAGGDW FTSRTSACGL FSVCYPRVSS AVKAELRQYF RNLCSDDTPM VRRAAASKLG EFAKVLELDN VKSEIIPMFS NLASDEQDSV RLLAVEACVN IAQLLPQEDL EALVMPTLRQ AAEDKSWRVR YMVADKFTEL QKAVGPEITK TDLVPAFQNL MKDCEAEVRA AASHKVKEFC ENLSADCREN VIMSQILPCI KELVSDANQH VKSALASVIM GLSPILGKDN TIEHLLPLFL AQLKDECPEV RLNIISNLDC VNEVIGIRQL SQSLLPAIVE LAEDAKWRVR LAIIEYMPLL AGQLGVEFFD EKLNSLCMAW LVDHVYAIRE AATSNLKKLV EKFGKEWAHA TIIPKVLAMS GDPNYLHRMT TLFCINVLSE VCGQDITTKH MLPTVLRMAG DPVANVRFNV AKSLQKIGPI LDNSTLQSEV KPILEKLTQD QDVDVKYFAQ EALTVLSLA
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