About Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) is a protein
from Homo sapiens identified by UniProt accession
P30154, 601 residues long.
MolForge cross-references it against 0 known binders and
175 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform |
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| UniProt accession | P30154 |
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| Gene | PPP2R1B |
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| Organism | Homo sapiens |
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| Length | 601 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (175)
Diseases linked to this target (Open Targets).
- cancer · score 0.53
- chronic myelogenous leukemia · score 0.37
- lung carcinoma · score 0.33
- triglyceride measurement · score 0.32
- BMI-adjusted waist-hip ratio · score 0.32
- glioblastoma multiforme · score 0.30
- endometrial cancer · score 0.30
- mean corpuscular volume · score 0.29
- BMI-adjusted waist circumference · score 0.29
- lung adenocarcinoma · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30154-F1 | alphafold | PREDICTED | 92.79 | — |
Amino-acid sequence (601 residues)
MAGASELGTG PGAAGGDGDD SLYPIAVLID ELRNEDVQLR LNSIKKLSTI ALALGVERTR SELLPFLTDT IYDEDEVLLA LAEQLGNFTG LVGGPDFAHC LLPPLENLAT VEETVVRDKA VESLRQISQE HTPVALEAYF VPLVKRLASG DWFTSRTSAC GLFSVCYPRA SNAVKAEIRQ QFRSLCSDDT PMVRRAAASK LGEFAKVLEL DSVKSEIVPL FTSLASDEQD SVRLLAVEAC VSIAQLLSQD DLETLVMPTL RQAAEDKSWR VRYMVADRFS ELQKAMGPKI TLNDLIPAFQ NLLKDCEAEV RAAAAHKVKE LGENLPIEDR ETIIMNQILP YIKELVSDTN QHVKSALASV IMGLSTILGK ENTIEHLLPL FLAQLKDECP DVRLNIISNL DCVNEVIGIR QLSQSLLPAI VELAEDAKWR VRLAIIEYMP LLAGQLGVEF FDEKLNSLCM AWLVDHVYAI REAATNNLMK LVQKFGTEWA QNTIVPKVLV MANDPNYLHR MTTLFCINAL SEACGQEITT KQMLPIVLKM AGDQVANVRF NVAKSLQKIG PILDTNALQG EVKPVLQKLG QDEDMDVKYF AQEAISVLAL A
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