G1/S-specific cyclin-D2 (CCND2)

About G1/S-specific cyclin-D2

G1/S-specific cyclin-D2 (CCND2) is a protein from Homo sapiens identified by UniProt accession P30279, 289 residues long. MolForge cross-references it against 0 known binders and 662 disease associations.

Target properties

Protein name	G1/S-specific cyclin-D2
UniProt accession	P30279
Gene	CCND2
Organism	Homo sapiens
Length	289 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (662)

Diseases linked to this target (Open Targets).

megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 · score 0.76
Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus · score 0.74
neurodegenerative disease · score 0.57
type 2 diabetes mellitus · score 0.50
diabetes mellitus · score 0.50
refractive error measurement · score 0.50
genetic disorder · score 0.49
chronic lymphocytic leukemia · score 0.48
lean body mass · score 0.48
body height · score 0.48

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P30279-F1	alphafold	PREDICTED	87.93	—

Amino-acid sequence (289 residues)

MELLCHEVDP VRRAVRDRNL LRDDRVLQNL LTIEERYLPQ CSYFKCVQKD IQPYMRRMVA TWMLEVCEEQ KCEEEVFPLA MNYLDRFLAG VPTPKSHLQL LGAVCMFLAS KLKETSPLTA EKLCIYTDNS IKPQELLEWE LVVLGKLKWN LAAVTPHDFI EHILRKLPQQ REKLSLIRKH AQTFIALCAT DFKFAMYPPS MIATGSVGAA ICGLQQDEEV SSLTCDALTE LLAKITNTDV DCLKACQEQI EAVLLNSLQQ YRQDQRDGSK SEDELDQAST PTDVRDIDL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards