About Wee1-like protein kinase
Wee1-like protein kinase (WEE1) is a protein
from Homo sapiens identified by UniProt accession
P30291, 646 residues long.
MolForge cross-references it against 0 known binders and
822 disease associations.
Target properties
| Protein name | Wee1-like protein kinase |
|---|
| UniProt accession | P30291 |
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| Gene | WEE1 |
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| Organism | Homo sapiens |
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| Length | 646 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (822)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- neuroinflammatory disorder · score 0.38
- platelet component distribution width · score 0.36
- glioblastoma multiforme · score 0.28
- cutaneous squamous cell carcinoma · score 0.27
- breast adenocarcinoma · score 0.27
- endometrial cancer · score 0.27
- lung adenocarcinoma · score 0.26
- head and neck squamous cell carcinoma · score 0.20
- acute myeloid leukemia · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30291-F1 | alphafold | PREDICTED | 65.33 | — |
Amino-acid sequence (646 residues)
MSFLSRQQPP PPRRAGAACT LRQKLIFSPC SDCEEEEEEE EEEGSGHSTG EDSAFQEPDS PLPPARSPTE PGPERRRSPG PAPGSPGELE EDLLLPGACP GADEAGGGAE GDSWEEEGFG SSSPVKSPAA PYFLGSSFSP VRCGGPGDAS PRGCGARRAG EGRRSPRPDH PGTPPHKTFR KLRLFDTPHT PKSLLSKARG IDSSSVKLRG SSLFMDTEKS GKREFDVRQT PQVNINPFTP DSLLLHSSGQ CRRRKRTYWN DSCGEDMEAS DYELEDETRP AKRITITESN MKSRYTTEFH ELEKIGSGEF GSVFKCVKRL DGCIYAIKRS KKPLAGSVDE QNALREVYAH AVLGQHSHVV RYFSAWAEDD HMLIQNEYCN GGSLADAISE NYRIMSYFKE AELKDLLLQV GRGLRYIHSM SLVHMDIKPS NIFISRTSIP NAASEEGDED DWASNKVMFK IGDLGHVTRI SSPQVEEGDS RFLANEVLQE NYTHLPKADI FALALTVVCA AGAEPLPRNG DQWHEIRQGR LPRIPQVLSQ EFTELLKVMI HPDPERRPSA MALVKHSVLL SASRKSAEQL RIELNAEKFK NSLLQKELKK AQMAKAAAEE RALFTDRMAT RSTTQSNRTS RLIGKKMNRS VSLTIY
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