About Lens fiber major intrinsic protein
Lens fiber major intrinsic protein (MIP) is a protein
from Homo sapiens identified by UniProt accession
P30301, 263 residues long.
MolForge cross-references it against 0 known binders and
217 disease associations.
Target properties
| Protein name | Lens fiber major intrinsic protein |
|---|
| UniProt accession | P30301 |
|---|
| Gene | MIP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 263 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (217)
Diseases linked to this target (Open Targets).
- Total congenital cataract · score 0.79
- Cataract with Y-shaped suture opacities · score 0.79
- cataract · score 0.65
- early-onset non-syndromic cataract · score 0.58
- lens disease · score 0.58
- Abnormal lens morphology · score 0.58
- Developmental cataract · score 0.56
- eye adnexa disease · score 0.55
- developmental defect of the eye · score 0.39
- Cataract · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30301-F1 | alphafold | PREDICTED | 91.03 | — |
Amino-acid sequence (263 residues)
MWELRSASFW RAIFAEFFAT LFYVFFGLGS SLRWAPGPLH VLQVAMAFGL ALATLVQSVG HISGAHVNPA VTFAFLVGSQ MSLLRAFCYM AAQLLGAVAG AAVLYSVTPP AVRGNLALNT LHPAVSVGQA TTVEIFLTLQ FVLCIFATYD ERRNGQLGSV ALAVGFSLAL GHLFGMYYTG AGMNPARSFA PAILTGNFTN HWVYWVGPII GGGLGSLLYD FLLFPRLKSI SERLSVLKGA KPDVSNGQPE VTGEPVELNT QAL
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