About M-phase inducer phosphatase 1
M-phase inducer phosphatase 1 (CDC25A) is a protein
from Homo sapiens identified by UniProt accession
P30304, 524 residues long.
MolForge cross-references it against 0 known binders and
196 disease associations.
Target properties
| Protein name | M-phase inducer phosphatase 1 |
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| UniProt accession | P30304 |
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| Gene | CDC25A |
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| Organism | Homo sapiens |
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| Length | 524 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (196)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- Alzheimer disease · score 0.37
- systolic blood pressure · score 0.31
- heel bone mineral density · score 0.30
- diastolic blood pressure · score 0.29
- hypertension · score 0.29
- Isolated polycystic liver disease · score 0.29
- autosomal dominant polycystic liver disease · score 0.29
- endometrial cancer · score 0.28
- breast adenocarcinoma · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30304-F1 | alphafold | PREDICTED | 62.99 | — |
Amino-acid sequence (524 residues)
MELGPEPPHR RRLLFACSPP PASQPVVKAL FGASAAGGLS PVTNLTVTMD QLQGLGSDYE QPLEVKNNSN LQRMGSSEST DSGFCLDSPG PLDSKENLEN PMRRIHSLPQ KLLGCSPALK RSHSDSLDHD IFQLIDPDEN KENEAFEFKK PVRPVSRGCL HSHGLQEGKD LFTQRQNSAP ARMLSSNERD SSEPGNFIPL FTPQSPVTAT LSDEDDGFVD LLDGENLKNE EETPSCMASL WTAPLVMRTT NLDNRCKLFD SPSLCSSSTR SVLKRPERSQ EESPPGSTKR RKSMSGASPK ESTNPEKAHE TLHQSLSLAS SPKGTIENIL DNDPRDLIGD FSKGYLFHTV AGKHQDLKYI SPEIMASVLN GKFANLIKEF VIIDCRYPYE YEGGHIKGAV NLHMEEEVED FLLKKPIVPT DGKRVIVVFH CEFSSERGPR MCRYVRERDR LGNEYPKLHY PELYVLKGGY KEFFMKCQSY CEPPSYRPMH HEDFKEDLKK FRTKSRTWAG EKSKREMYSR LKKL
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