About M-phase inducer phosphatase 2
M-phase inducer phosphatase 2 (CDC25B) is a protein
from Homo sapiens identified by UniProt accession
P30305, 580 residues long.
MolForge cross-references it against 0 known binders and
176 disease associations.
Target properties
| Protein name | M-phase inducer phosphatase 2 |
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| UniProt accession | P30305 |
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| Gene | CDC25B |
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| Organism | Homo sapiens |
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| Length | 580 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (176)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.60
- neurodegenerative disease · score 0.56
- lysosomal storage disease · score 0.50
- Parkinson disease · score 0.50
- multiple sclerosis · score 0.50
- mean corpuscular volume · score 0.39
- mean corpuscular hemoglobin · score 0.32
- mean reticulocyte volume · score 0.30
- erythrocyte count · score 0.28
- lymphocyte percentage of leukocytes · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30305-F1 | alphafold | PREDICTED | 63.56 | — |
Amino-acid sequence (580 residues)
MEVPQPEPAP GSALSPAGVC GGAQRPGHLP GLLLGSHGLL GSPVRAAASS PVTTLTQTMH DLAGLGSETP KSQVGTLLFR SRSRLTHLSL SRRASESSLS SESSESSDAG LCMDSPSPMD PHMAEQTFEQ AIQAASRIIR NEQFAIRRFQ SMPVRLLGHS PVLRNITNSQ APDGRRKSEA GSGAASSSGE DKENDGFVFK MPWKPTHPSS THALAEWASR REAFAQRPSS APDLMCLSPD RKMEVEELSP LALGRFSLTP AEGDTEEDDG FVDILESDLK DDDAVPPGME SLISAPLVKT LEKEEEKDLV MYSKCQRLFR SPSMPCSVIR PILKRLERPQ DRDTPVQNKR RRSVTPPEEQ QEAEEPKARV LRSKSLCHDE IENLLDSDHR ELIGDYSKAF LLQTVDGKHQ DLKYISPETM VALLTGKFSN IVDKFVIVDC RYPYEYEGGH IKTAVNLPLE RDAESFLLKS PIAPCSLDKR VILIFHCEFS SERGPRMCRF IRERDRAVND YPSLYYPEMY ILKGGYKEFF PQHPNFCEPQ DYRPMNHEAF KDELKTFRLK TRSWAGERSR RELCSRLQDQ
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