About Peptidyl-prolyl cis-trans isomerase F, mitochondrial
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF) is a protein
from Homo sapiens identified by UniProt accession
P30405, 207 residues long.
MolForge cross-references it against 0 known binders and
155 disease associations.
Target properties
| Protein name | Peptidyl-prolyl cis-trans isomerase F, mitochondrial |
|---|
| UniProt accession | P30405 |
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| Gene | PPIF |
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| Organism | Homo sapiens |
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| Length | 207 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (155)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- body height · score 0.39
- reticulocyte count · score 0.39
- lean body mass · score 0.37
- sex hormone-binding globulin measurement · score 0.36
- triglyceride measurement · score 0.36
- reticulocyte measurement · score 0.35
- mean platelet volume · score 0.35
- platelet count · score 0.33
- appendicular lean mass · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30405-F1 | alphafold | PREDICTED | 88.29 | — |
Amino-acid sequence (207 residues)
MLALRCGSRW LGLLSVPRSV PLRLPAARAC SKGSGDPSSS SSSGNPLVYL DVDANGKPLG RVVLELKADV VPKTAENFRA LCTGEKGFGY KGSTFHRVIP SFMCQAGDFT NHNGTGGKSI YGSRFPDENF TLKHVGPGVL SMANAGPNTN GSQFFICTIK TDWLDGKHVV FGHVKEGMDV VKKIESFGSK SGRTSKKIVI TDCGQLS
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