About Glycylpeptide N-tetradecanoyltransferase 1
Glycylpeptide N-tetradecanoyltransferase 1 (NMT1) is a protein
from Homo sapiens identified by UniProt accession
P30419, 496 residues long.
MolForge cross-references it against 0 known binders and
134 disease associations.
Target properties
| Protein name | Glycylpeptide N-tetradecanoyltransferase 1 |
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| UniProt accession | P30419 |
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| Gene | NMT1 |
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| Organism | Homo sapiens |
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| Length | 496 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (134)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- HIV infection · score 0.37
- breast adenocarcinoma · score 0.26
- head and neck squamous cell carcinoma · score 0.23
- systolic blood pressure · score 0.23
- diastolic blood pressure · score 0.21
- lung adenocarcinoma · score 0.19
- urinary bladder cancer · score 0.18
- endometrial cancer · score 0.18
- gastric adenocarcinoma · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30419-F1 | alphafold | PREDICTED | 83.28 | — |
Amino-acid sequence (496 residues)
MADESETAVK PPAPPLPQMM EGNGNGHEHC SDCENEEDNS YNRGGLSPAN DTGAKKKKKK QKKKKEKGSE TDSAQDQPVK MNSLPAERIQ EIQKAIELFS VGQGPAKTME EASKRSYQFW DTQPVPKLGE VVNTHGPVEP DKDNIRQEPY TLPQGFTWDA LDLGDRGVLK ELYTLLNENY VEDDDNMFRF DYSPEFLLWA LRPPGWLPQW HCGVRVVSSR KLVGFISAIP ANIHIYDTEK KMVEINFLCV HKKLRSKRVA PVLIREITRR VHLEGIFQAV YTAGVVLPKP VGTCRYWHRS LNPRKLIEVK FSHLSRNMTM QRTMKLYRLP ETPKTAGLRP METKDIPVVH QLLTRYLKQF HLTPVMSQEE VEHWFYPQEN IIDTFVVENA NGEVTDFLSF YTLPSTIMNH PTHKSLKAAY SFYNVHTQTP LLDLMSDALV LAKMKGFDVF NALDLMENKT FLEKLKFGIG DGNLQYYLYN WKCPSMGAEK VGLVLQ
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