About Neuronal acetylcholine receptor subunit alpha-5
Neuronal acetylcholine receptor subunit alpha-5 (CHRNA5) is a protein
from Homo sapiens identified by UniProt accession
P30532, 468 residues long.
MolForge cross-references it against 0 known binders and
203 disease associations.
Target properties
| Protein name | Neuronal acetylcholine receptor subunit alpha-5 |
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| UniProt accession | P30532 |
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| Gene | CHRNA5 |
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| Organism | Homo sapiens |
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| Length | 468 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (203)
Diseases linked to this target (Open Targets).
- chronic obstructive pulmonary disease · score 0.45
- lung carcinoma · score 0.41
- forced expiratory volume · score 0.41
- parental longevity · score 0.39
- cigarettes per day measurement · score 0.38
- non-small cell lung carcinoma · score 0.38
- lung adenocarcinoma · score 0.37
- non-small cell lung adenocarcinoma · score 0.35
- emphysema · score 0.35
- FEV/FVC ratio · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30532-F1 | alphafold | PREDICTED | 81.19 | — |
Amino-acid sequence (468 residues)
MAARGSGPRA LRLLLLVQLV AGRCGLAGAA GGAQRGLSEP SSIAKHEDSL LKDLFQDYER WVRPVEHLND KIKIKFGLAI SQLVDVDEKN QLMTTNVWLK QEWIDVKLRW NPDDYGGIKV IRVPSDSVWT PDIVLFDNAD GRFEGTSTKT VIRYNGTVTW TPPANYKSSC TIDVTFFPFD LQNCSMKFGS WTYDGSQVDI ILEDQDVDKR DFFDNGEWEI VSATGSKGNR TDSCCWYPYV TYSFVIKRLP LFYTLFLIIP CIGLSFLTVL VFYLPSNEGE KICLCTSVLV SLTVFLLVIE EIIPSSSKVI PLIGEYLVFT MIFVTLSIMV TVFAINIHHR SSSTHNAMAP LVRKIFLHTL PKLLCMRSHV DRYFTQKEET ESGSGPKSSR NTLEAALDSI RYITRHIMKE NDVREVVEDW KFIAQVLDRM FLWTFLFVSI VGSLGLFVPV IYKWANILIP VHIGNANK
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