Adenylosuccinate lyase (ADSL)

About Adenylosuccinate lyase

Adenylosuccinate lyase (ADSL) is a protein from Homo sapiens identified by UniProt accession P30566, 484 residues long. MolForge cross-references it against 0 known binders and 455 disease associations.

Target properties

Protein name	Adenylosuccinate lyase
UniProt accession	P30566
Gene	ADSL
Organism	Homo sapiens
Length	484 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (455)

Diseases linked to this target (Open Targets).

adenylosuccinate lyase deficiency · score 0.85
neurodegenerative disease · score 0.53
genetic disorder · score 0.48
Intellectual disability · score 0.46
Epileptic encephalopathy · score 0.46
Progressive neurologic deterioration · score 0.43
Inability to walk · score 0.43
Difficulty standing · score 0.43
Generalized myoclonic seizure · score 0.43
Severe global developmental delay · score 0.43

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P30566-F1	alphafold	PREDICTED	96.55	—

Amino-acid sequence (484 residues)

MAAGGDHGSP DSYRSPLASR YASPEMCFVF SDRYKFRTWR QLWLWLAEAE QTLGLPITDE QIQEMKSNLE NIDFKMAAEE EKRLRHDVMA HVHTFGHCCP KAAGIIHLGA TSCYVGDNTD LIILRNALDL LLPKLARVIS RLADFAKERA SLPTLGFTHF QPAQLTTVGK RCCLWIQDLC MDLQNLKRVR DDLRFRGVKG TTGTQASFLQ LFEGDDHKVE QLDKMVTEKA GFKRAFIITG QTYTRKVDIE VLSVLASLGA SVHKICTDIR LLANLKEMEE PFEKQQIGSS AMPYKRNPMR SERCCSLARH LMTLVMDPLQ TASVQWFERT LDDSANRRIC LAEAFLTADT ILNTLQNISE GLVVYPKVIE RRIRQELPFM ATENIIMAMV KAGGSRQDCH EKIRVLSQQA ASVVKQEGGD NDLIERIQVD AYFSPIHSQL DHLLDPSSFT GRASQQVQRF LEEEVYPLLK PYESVMKVKA ELCL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards