About Pyruvate kinase PKLR
Pyruvate kinase PKLR (PKLR) is a protein
from Homo sapiens identified by UniProt accession
P30613, 574 residues long.
MolForge cross-references it against 0 known binders and
375 disease associations.
Target properties
| Protein name | Pyruvate kinase PKLR |
|---|
| UniProt accession | P30613 |
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| Gene | PKLR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 574 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (375)
Diseases linked to this target (Open Targets).
- pyruvate kinase deficiency of red cells · score 0.86
- Hemolytic anemia due to red cell pyruvate kinase deficiency · score 0.76
- Pyruvate kinase hyperactivity · score 0.67
- reticulocyte count · score 0.62
- reticulocyte measurement · score 0.60
- erythrocyte count · score 0.53
- genetic disorder · score 0.51
- hemoglobin measurement · score 0.49
- hematocrit · score 0.48
- familial hemolytic anemia · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30613-F1 | alphafold | PREDICTED | 90.68 | — |
Amino-acid sequence (574 residues)
MSIQENISSL QLRSWVSKSQ RDLAKSILIG APGGPAGYLR RASVAQLTQE LGTAFFQQQQ LPAAMADTFL EHLCLLDIDS EPVAARSTSI IATIGPASRS VERLKEMIKA GMNIARLNFS HGSHEYHAES IANVREAVES FAGSPLSYRP VAIALDTKGP EIRTGILQGG PESEVELVKG SQVLVTVDPA FRTRGNANTV WVDYPNIVRV VPVGGRIYID DGLISLVVQK IGPEGLVTQV ENGGVLGSRK GVNLPGAQVD LPGLSEQDVR DLRFGVEHGV DIVFASFVRK ASDVAAVRAA LGPEGHGIKI ISKIENHEGV KRFDEILEVS DGIMVARGDL GIEIPAEKVF LAQKMMIGRC NLAGKPVVCA TQMLESMITK PRPTRAETSD VANAVLDGAD CIMLSGETAK GNFPVEAVKM QHAIAREAEA AVYHRQLFEE LRRAAPLSRD PTEVTAIGAV EAAFKCCAAA IIVLTTTGRS AQLLSRYRPR AAVIAVTRSA QAARQVHLCR GVFPLLYREP PEAIWADDVD RRVQFGIESG KLRGFLRVGD LVIVVTGWRP GSGYTNIMRV LSIS
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