About Guanine nucleotide-binding protein subunit alpha-15
Guanine nucleotide-binding protein subunit alpha-15 (GNA15) is a protein
from Homo sapiens identified by UniProt accession
P30679, 374 residues long.
MolForge cross-references it against 0 known binders and
88 disease associations.
Target properties
| Protein name | Guanine nucleotide-binding protein subunit alpha-15 |
|---|
| UniProt accession | P30679 |
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| Gene | GNA15 |
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| Organism | Homo sapiens |
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| Length | 374 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (88)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.30
- thyroid gland adenocarcinoma · score 0.22
- glioblastoma multiforme · score 0.18
- asthma · score 0.18
- cutaneous melanoma · score 0.16
- atopic asthma · score 0.12
- respiratory system disease · score 0.12
- neutrophil percentage of leukocytes · score 0.11
- neutrophil count · score 0.11
- acute myeloid leukemia · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30679-F1 | alphafold | PREDICTED | 90.59 | — |
Amino-acid sequence (374 residues)
MARSLTWRCC PWCLTEDEKA AARVDQEINR ILLEQKKQDR GELKLLLLGP GESGKSTFIK QMRIIHGAGY SEEERKGFRP LVYQNIFVSM RAMIEAMERL QIPFSRPESK HHASLVMSQD PYKVTTFEKR YAAAMQWLWR DAGIRACYER RREFHLLDSA VYYLSHLERI TEEGYVPTAQ DVLRSRMPTT GINEYCFSVQ KTNLRIVDVG GQKSERKKWI HCFENVIALI YLASLSEYDQ CLEENNQENR MKESLALFGT ILELPWFKST SVILFLNKTD ILEEKIPTSH LATYFPSFQG PKQDAEAAKR FILDMYTRMY TGCVDGPEGS KKGARSRRLF SHYTCATDTQ NIRKVFKDVR DSVLARYLDE INLL
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