About Glutathione S-transferase theta-1
Glutathione S-transferase theta-1 (GSTT1) is a protein
from Homo sapiens identified by UniProt accession
P30711, 240 residues long.
MolForge cross-references it against 0 known binders and
449 disease associations.
Target properties
| Protein name | Glutathione S-transferase theta-1 |
|---|
| UniProt accession | P30711 |
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| Gene | GSTT1 |
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| Organism | Homo sapiens |
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| Length | 240 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (449)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.10
- renal cell carcinoma · score 0.10
- urinary bladder carcinoma · score 0.10
- breast cancer · score 0.10
- chronic myelogenous leukemia · score 0.10
- endometriosis · score 0.10
- chronic obstructive pulmonary disease · score 0.09
- cancer · score 0.09
- acute lymphoblastic leukemia · score 0.09
- hepatocellular carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30711-F1 | alphafold | PREDICTED | 97.80 | — |
Amino-acid sequence (240 residues)
MGLELYLDLL SQPCRAVYIF AKKNDIPFEL RIVDLIKGQH LSDAFAQVNP LKKVPALKDG DFTLTESVAI LLYLTRKYKV PDYWYPQDLQ ARARVDEYLA WQHTTLRRSC LRALWHKVMF PVFLGEPVSP QTLAATLAEL DVTLQLLEDK FLQNKAFLTG PHISLADLVA ITELMHPVGA GCQVFEGRPK LATWRQRVEA AVGEDLFQEA HEVILKAKDF PPADPTIKQK LMPWVLAMIR
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