About GTP cyclohydrolase 1
GTP cyclohydrolase 1 (GCH1) is a protein
from Homo sapiens identified by UniProt accession
P30793, 250 residues long.
MolForge cross-references it against 0 known binders and
341 disease associations.
Target properties
| Protein name | GTP cyclohydrolase 1 |
|---|
| UniProt accession | P30793 |
|---|
| Gene | GCH1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 250 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (341)
Diseases linked to this target (Open Targets).
- dystonia 5 · score 0.84
- GTP cyclohydrolase I deficiency with hyperphenylalaninemia · score 0.80
- Hyperphenylalaninemia · score 0.78
- GTP cyclohydrolase I deficiency · score 0.70
- dopa-responsive dystonia · score 0.66
- Dystonia · score 0.60
- Spastic paraplegia · score 0.52
- Autosomal recessive dopa-responsive dystonia · score 0.50
- dystonic disorder · score 0.46
- genetic disorder · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30793-F1 | alphafold | PREDICTED | 86.50 | — |
Amino-acid sequence (250 residues)
MEKGPVRAPA EKPRGARCSN GFPERDPPRP GPSRPAEKPP RPEAKSAQPA DGWKGERPRS EEDNELNLPN LAAAYSSILS SLGENPQRQG LLKTPWRAAS AMQFFTKGYQ ETISDVLNDA IFDEDHDEMV IVKDIDMFSM CEHHLVPFVG KVHIGYLPNK QVLGLSKLAR IVEIYSRRLQ VQERLTKQIA VAITEALRPA GVGVVVEATH MCMVMRGVQK MNSKTVTSTM LGVFREDPKT REEFLTLIRS
Explore GTP cyclohydrolase 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets