Aldehyde dehydrogenase X, mitochondrial (ALDH1B1)

About Aldehyde dehydrogenase X, mitochondrial

Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) is a protein from Homo sapiens identified by UniProt accession P30837, 517 residues long. MolForge cross-references it against 0 known binders and 118 disease associations.

Target properties

Protein name	Aldehyde dehydrogenase X, mitochondrial
UniProt accession	P30837
Gene	ALDH1B1
Organism	Homo sapiens
Length	517 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (118)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
smoking status measurement · score 0.33
blood protein measurement · score 0.29
alcohol drinking · score 0.29
smoking behavior · score 0.27
gut microbiome measurement · score 0.26
longevity · score 0.25
Dental crowding · score 0.20
genetic disorder · score 0.15
platelet count · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P30837-F1	alphafold	PREDICTED	95.50	—

Amino-acid sequence (517 residues)

MLRFLAPRLL SLQGRTARYS SAAALPSPIL NPDIPYNQLF INNEWQDAVS KKTFPTVNPT TGEVIGHVAE GDRADVDRAV KAAREAFRLG SPWRRMDASE RGRLLNRLAD LVERDRVYLA SLETLDNGKP FQESYALDLD EVIKVYRYFA GWADKWHGKT IPMDGQHFCF TRHEPVGVCG QIIPWNFPLV MQGWKLAPAL ATGNTVVMKV AEQTPLSALY LASLIKEAGF PPGVVNIITG YGPTAGAAIA QHVDVDKVAF TGSTEVGHLI QKAAGDSNLK RVTLELGGKS PSIVLADADM EHAVEQCHEA LFFNMGQCCC AGSRTFVEES IYNEFLERTV EKAKQRKVGN PFELDTQQGP QVDKEQFERV LGYIQLGQKE GAKLLCGGER FGERGFFIKP TVFGGVQDDM RIAKEEIFGP VQPLFKFKKI EEVVERANNT RYGLAAAVFT RDLDKAMYFT QALQAGTVWV NTYNIVTCHT PFGGFKESGN GRELGEDGLK AYTEVKTVTI KVPQKNS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards