About Aldehyde dehydrogenase, dimeric NADP-preferring
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) is a protein
from Homo sapiens identified by UniProt accession
P30838, 453 residues long.
MolForge cross-references it against 0 known binders and
121 disease associations.
Target properties
| Protein name | Aldehyde dehydrogenase, dimeric NADP-preferring |
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| UniProt accession | P30838 |
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| Gene | ALDH3A1 |
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| Organism | Homo sapiens |
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| Length | 453 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (121)
Diseases linked to this target (Open Targets).
- keratoconus · score 0.36
- blood protein measurement · score 0.33
- neurodegenerative disease · score 0.33
- intraocular pressure measurement · score 0.29
- glioblastoma multiforme · score 0.16
- urinary bladder cancer · score 0.11
- mean corpuscular hemoglobin concentration · score 0.11
- neoplasm · score 0.10
- oral squamous cell carcinoma · score 0.10
- non-small cell lung carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30838-F1 | alphafold | PREDICTED | 97.93 | — |
Amino-acid sequence (453 residues)
MSKISEAVKR ARAAFSSGRT RPLQFRIQQL EALQRLIQEQ EQELVGALAA DLHKNEWNAY YEEVVYVLEE IEYMIQKLPE WAADEPVEKT PQTQQDELYI HSEPLGVVLV IGTWNYPFNL TIQPMVGAIA AGNSVVLKPS ELSENMASLL ATIIPQYLDK DLYPVINGGV PETTELLKER FDHILYTGST GVGKIIMTAA AKHLTPVTLE LGGKSPCYVD KNCDLDVACR RIAWGKFMNS GQTCVAPDYI LCDPSIQNQI VEKLKKSLKE FYGEDAKKSR DYGRIISARH FQRVMGLIEG QKVAYGGTGD AATRYIAPTI LTDVDPQSPV MQEEIFGPVL PIVCVRSLEE AIQFINQREK PLALYMFSSN DKVIKKMIAE TSSGGVAAND VIVHITLHSL PFGGVGNSGM GSYHGKKSFE TFSHRRSCLV RPLMNDEGLK VRYPPSPAKM TQH
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