About Neuronal acetylcholine receptor subunit beta-4
Neuronal acetylcholine receptor subunit beta-4 (CHRNB4) is a protein
from Homo sapiens identified by UniProt accession
P30926, 498 residues long.
MolForge cross-references it against 0 known binders and
155 disease associations.
Target properties
| Protein name | Neuronal acetylcholine receptor subunit beta-4 |
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| UniProt accession | P30926 |
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| Gene | CHRNB4 |
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| Organism | Homo sapiens |
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| Length | 498 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (155)
Diseases linked to this target (Open Targets).
- hypertension · score 0.47
- coronary artery disease · score 0.43
- angina pectoris · score 0.39
- neuroinflammatory disorder · score 0.37
- myocardial infarction · score 0.37
- body mass index · score 0.36
- smoking behavior · score 0.34
- frontotemporal dementia · score 0.32
- celiac disease · score 0.30
- aneurysm · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P30926-F1 | alphafold | PREDICTED | 81.31 | — |
Amino-acid sequence (498 residues)
MRRAPSLVLF FLVALCGRGN CRVANAEEKL MDDLLNKTRY NNLIRPATSS SQLISIKLQL SLAQLISVNE REQIMTTNVW LKQEWTDYRL TWNSSRYEGV NILRIPAKRI WLPDIVLYNN ADGTYEVSVY TNLIVRSNGS VLWLPPAIYK SACKIEVKYF PFDQQNCTLK FRSWTYDHTE IDMVLMTPTA SMDDFTPSGE WDIVALPGRR TVNPQDPSYV DVTYDFIIKR KPLFYTINLI IPCVLTTLLA ILVFYLPSDC GEKMTLCISV LLALTFFLLL ISKIVPPTSL DVPLIGKYLM FTMVLVTFSI VTSVCVLNVH HRSPSTHTMA PWVKRCFLHK LPTFLFMKRP GPDSSPARAF PPSKSCVTKP EATATSTSPS NFYGNSMYFV NPASAASKSP AGSTPVAIPR DFWLRSSGRF RQDVQEALEG VSFIAQHMKN DDEDQSVVED WKYVAMVVDR LFLWVFMFVC VLGTVGLFLP PLFQTHAASE GPYAAQRD
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