Calcitonin receptor (CALCR)

About Calcitonin receptor

Calcitonin receptor (CALCR) is a protein from Homo sapiens identified by UniProt accession P30988, 474 residues long. MolForge cross-references it against 0 known binders and 224 disease associations.

Target properties

Protein name	Calcitonin receptor
UniProt accession	P30988
Gene	CALCR
Organism	Homo sapiens
Length	474 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (224)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.66
type 1 diabetes mellitus · score 0.57
postmenopausal osteoporosis · score 0.53
body mass index · score 0.49
diabetes mellitus · score 0.47
bone fracture · score 0.46
parathyroid disease · score 0.46
pain · score 0.46
lean body mass · score 0.42
triglyceride measurement · score 0.39

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P30988-F1	alphafold	PREDICTED	78.69	—

Amino-acid sequence (474 residues)

MRFTFTSRCL ALFLLLNHPT PILPAFSNQT YPTIEPKPFL YVVGRKKMMD AQYKCYDRMQ QLPAYQGEGP YCNRTWDGWL CWDDTPAGVL SYQFCPDYFP DFDPSEKVTK YCDEKGVWFK HPENNRTWSN YTMCNAFTPE KLKNAYVLYY LAIVGHSLSI FTLVISLGIF VFFRSLGCQR VTLHKNMFLT YILNSMIIII HLVEVVPNGE LVRRDPVSCK ILHFFHQYMM ACNYFWMLCE GIYLHTLIVV AVFTEKQRLR WYYLLGWGFP LVPTTIHAIT RAVYFNDNCW LSVETHLLYI IHGPVMAALV VNFFFLLNIV RVLVTKMRET HEAESHMYLK AVKATMILVP LLGIQFVVFP WRPSNKMLGK IYDYVMHSLI HFQGFFVATI YCFCNNEVQT TVKRQWAQFK IQWNQRWGRR PSNRSARAAA AAAEAGDIPI YICHQELRNE PANNQGEESA EIIPLNIIEQ ESSA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards