Neurotensin receptor type 1 (NTSR1)

About Neurotensin receptor type 1

Neurotensin receptor type 1 (NTSR1) is a protein from Homo sapiens identified by UniProt accession P30989, 418 residues long. MolForge cross-references it against 0 known binders and 229 disease associations.

Target properties

Protein name	Neurotensin receptor type 1
UniProt accession	P30989
Gene	NTSR1
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (229)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.28
PHF-tau measurement · score 0.27
C-reactive protein measurement · score 0.27
breast adenocarcinoma · score 0.25
low density lipoprotein cholesterol measurement · score 0.24
head and neck squamous cell carcinoma · score 0.17
low grade glioma · score 0.14
adolescent idiopathic scoliosis · score 0.13
serum gamma-glutamyl transferase measurement · score 0.13
Cough · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P30989-F1	alphafold	PREDICTED	79.62	—

Amino-acid sequence (418 residues)

MRLNSSAPGT PGTPAADPFQ RAQAGLEEAL LAPGFGNASG NASERVLAAP SSELDVNTDI YSKVLVTAVY LALFVVGTVG NTVTAFTLAR KKSLQSLQST VHYHLGSLAL SDLLTLLLAM PVELYNFIWV HHPWAFGDAG CRGYYFLRDA CTYATALNVA SLSVERYLAI CHPFKAKTLM SRSRTKKFIS AIWLASALLA VPMLFTMGEQ NRSADGQHAG GLVCTPTIHT ATVKVVIQVN TFMSFIFPMV VISVLNTIIA NKLTVMVRQA AEQGQVCTVG GEHSTFSMAI EPGRVQALRH GVRVLRAVVI AFVVCWLPYH VRRLMFCYIS DEQWTPFLYD FYHYFYMVTN ALFYVSSTIN PILYNLVSAN FRHIFLATLA CLCPVWRRRR KRPAFSRKAD SVSSNHTLSS NATRETLY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards