About Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA) is a protein
from Homo sapiens identified by UniProt accession
P31040, 664 residues long.
MolForge cross-references it against 0 known binders and
341 disease associations.
Target properties
| Protein name | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
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| UniProt accession | P31040 |
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| Gene | SDHA |
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| Organism | Homo sapiens |
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| Length | 664 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (341)
Diseases linked to this target (Open Targets).
- mitochondrial complex II deficiency, nuclear type 1 · score 0.81
- paragangliomas 5 · score 0.77
- dilated cardiomyopathy 1GG · score 0.76
- Leigh syndrome · score 0.74
- neurodegeneration with ataxia and late-onset optic atrophy · score 0.73
- gastrointestinal stromal tumor · score 0.72
- hereditary pheochromocytoma-paraganglioma · score 0.58
- hereditary neoplastic syndrome · score 0.57
- Inherited cancer-predisposing syndrome · score 0.57
- mitochondrial disease · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31040-F1 | alphafold | PREDICTED | 93.96 | — |
Amino-acid sequence (664 residues)
MSGVRGLSRL LSARRLALAK AWPTVLQTGT RGFHFTVDGN KRASAKVSDS ISAQYPVVDH EFDAVVVGAG GAGLRAAFGL SEAGFNTACV TKLFPTRSHT VAAQGGINAA LGNMEEDNWR WHFYDTVKGS DWLGDQDAIH YMTEQAPAAV VELENYGMPF SRTEDGKIYQ RAFGGQSLKF GKGGQAHRCC CVADRTGHSL LHTLYGRSLR YDTSYFVEYF ALDLLMENGE CRGVIALCIE DGSIHRIRAK NTVVATGGYG RTYFSCTSAH TSTGDGTAMI TRAGLPCQDL EFVQFHPTGI YGAGCLITEG CRGEGGILIN SQGERFMERY APVAKDLASR DVVSRSMTLE IREGRGCGPE KDHVYLQLHH LPPEQLATRL PGISETAMIF AGVDVTKEPI PVLPTVHYNM GGIPTNYKGQ VLRHVNGQDQ IVPGLYACGE AACASVHGAN RLGANSLLDL VVFGRACALS IEESCRPGDK VPPIKPNAGE ESVMNLDKLR FADGSIRTSE LRLSMQKSMQ NHAAVFRVGS VLQEGCGKIS KLYGDLKHLK TFDRGMVWNT DLVETLELQN LMLCALQTIY GAEARKESRG AHAREDYKVR IDEYDYSKPI QGQQKKPFEE HWRKHTLSYV DVGTGKVTLE YRPVIDKTLN EADCATVPPA IRSY
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