Coronin-1A (CORO1A)

About Coronin-1A

Coronin-1A (CORO1A) is a protein from Homo sapiens identified by UniProt accession P31146, 461 residues long. MolForge cross-references it against 0 known binders and 344 disease associations.

Target properties

Protein name	Coronin-1A
UniProt accession	P31146
Gene	CORO1A
Organism	Homo sapiens
Length	461 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (344)

Diseases linked to this target (Open Targets).

severe combined immunodeficiency due to CORO1A deficiency · score 0.75
neurodegenerative disease · score 0.49
Combined immunodeficiency · score 0.46
combined immunodeficiency · score 0.46
Omenn syndrome · score 0.46
tuberculosis · score 0.37
severe combined immunodeficiency · score 0.27
sinoatrial node disorder · score 0.26
genetic disorder · score 0.19
tonsillectomy risk measurement · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P31146-F1	alphafold	PREDICTED	93.06	—

Amino-acid sequence (461 residues)

MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQTTWDSGFC AVNPKFVALI CEASGGGAFL VLPLGKTGRV DKNAPTVCGH TAPVLDIAWC PHNDNVIASG SEDCTVMVWE IPDGGLMLPL REPVVTLEGH TKRVGIVAWH TTAQNVLLSA GCDNVIMVWD VGTGAAMLTL GPEVHPDTIY SVDWSRDGGL ICTSCRDKRV RIIEPRKGTV VAEKDRPHEG TRPVRAVFVS EGKILTTGFS RMSERQVALW DTKHLEEPLS LQELDTSSGV LLPFFDPDTN IVYLCGKGDS SIRYFEITSE APFLHYLSMF SSKESQRGMG YMPKRGLEVN KCEIARFYKL HERRCEPIAM TVPRKSDLFQ EDLYPPTAGP DPALTAEEWL GGRDAGPLLI SLKDGYVPPK SRELRVNRGL DTGRRRAAPE ASGTPSSDAV SRLEEEMRKL QATVQELQKR LDRLEETVQA K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards